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Hundreds of studies have linked small changes in weight to big benefits: Lower blood pressure : Reducing BMI by just 2.27 pointse.g., going from a BMI of 26 to a BMI of 23.7, or losing about 20 poundscan lower systolic and diastolic blood pressure by 5.79 mmHg and 3.36 mmHg, respectively

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In these rodents, GLP-1 medications were found to stimulate "C-cells" in the thyroid, leading to a rare type of cancer called Medullary Thyroid Cancer (MTC)