Expert Opin Drug Discovery (2014) 9:122351
Liraglutide Attenuates Preestablished Atherosclerosis in Apolipoprotein E-Deficient Mice via Regulation of Immune Cell Phenotypes and Proinflammatory Mediators
GLP-1 (glucagon-like peptide-1) receptor agonists are injectable medications that mimic a hormone your body naturally produces after eating
only the delivery mechanism is new
24 Small molecules may offer advantages such as improved tissue permeability, longer half-lives, and lower production costs
In this regard, GLP-1 treatment leads to decreased expression of macrophagespecific markers for M1 (inducible NOS (iNOS), IL6 and TNF) and enhances expression level of M2-marker genes, including arginine1, macrophage galectin-1 (MGL-1), IL10, as well as mannose receptor-1 (MRC-1)