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Many cases can be controlled through lifestyle changes, oral medications, or sometimes insulin

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Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high grade prostate cancer

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SGLT2 inhibitorrelated adverse effects, including genital mycotic infections, volume depletion, and rarely ketoacidosis, remain clinically relevant and should be considered when these agents are prescribed as part of combination therapy and importantly, the intrinsic risk of hypoglycemia with combined GLP-1 receptor agonist and SGLT2 inhibitor therapy is low because neither class directly stimulates insulin secretion in a glucose-independent manner and when hypoglycemia occurs, it is more commonly related to concomitant insulin or sulfonylurea use rather than the combination itself [41, 42, 44]

For 2027 plan year, watch for Open Enrollment in late 2026