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Results Induction of localized BDNF reduction We designed four different sequences of shRNAs complementary to the coding exon of the rat BDNF gene, that is common to all isoforms of this gene, 28 and then tested which sequence most effectively reduces BDNF levels in vitro (Supplementary Figure 1)

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J Am Chem Soc 126:1645616465 [DOI] [PubMed] [Google Scholar] Valko M, Izakovic M, Mazur M, Rhodes CJ, Telser J (2004) Role of oxygen radicals in DNA damage and cancer incidence