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The researchers took care to rule out potential biases, such as effects due to the sequence of medication use or carryover effects between treatment periods

Patients should discuss risks carefully if they have: A history of pancreatitis Severe nausea, vomiting, or gastroparesis Gallbladder disease Severe dehydration risk Advanced kidney disease with frequent vomiting or poor oral intake A personal or family history of medullary thyroid cancer Multiple endocrine neoplasia syndrome type 2 Pregnancy, plans for pregnancy, or breastfeeding Also, if you have active lupus nephritis or unstable lupus, your rheumatologist and nephrologist should be involved before starting any new medicine that could affect hydration, nutrition, kidney function, or medication tolerance

After considering those comments, the agency would decide whether to issue a final rule, explaining any revisions and responding to significant public feedback

doi: 10.1016/j.jhep.2015.04.006