Pharmacokinetics & drug-delivery barriers Many ferroptosis inhibitors are lipophilic small molecules that suffer from rapid metabolism and clearance, yielding subtherapeutic bioavailability in cardiac tissue
Brendan Gates: Yeah
Liu J, Su H, Jin X, Wang L, Huang J
As described here in the Experimental section in Methods and Results, it has been possible to obtain some estimate of the limiting solubility of niclosamide from nanodrop UV/Vis by evaluating two noisy scans, i.e., one for the blank buffer and one for the niclosamide solution at pH 3.66, where the niclosamide solubility is expected to be its absolute lowest
Additionally, evidence of axonal degeneration is found in peripheral neural structures
Beatty, S., Koh, H., Phil, M., Henson, D., & Boulton, M