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In women with episodic migraines ( n = 92), ALA (300 mg twice daily) for 12 weeks significantly reduced migraine severity and frequency, and reduced serum lactate and vascular cell adhesion molecule-1, suggesting improvement in mitochondrial and endothelial function, respectively

Figure 3B and E show the results from the PLS-DA of SF samples, in which components 12 perfectly separated the control and KOA SFs, as well as the control and RA SFs, indicating perturbations in AA metabolism in both joint diseases

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