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This delayed gastric emptying may lead to increased acid buildup or allow stomach acid more opportunity to irritate the esophagus, making reflux or heartburn more likely

doi:10.2337/db13-1087

Greenwood-Van Meerveld et al., "Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus," J

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Of the other sites we propose, some are more likely than others, but those in TXNRD1 and SELENOF are particularly convincing, and all of the predicted sites map to surface accessible regions of the targeted proteins (Figure S3)