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Hydroquinone (HQ), another well-studied whitening agent, has been used clinically in leading cosmetic hyperpigmentation treatment 23 , however, it was also found to cause serious problems by generating reactive oxygen species leading to oxidative damage of lipids and permanent loss of melanocytes

A population-based cohort study of Medicare beneficiaries with heart failure with preserved ejection fraction (HFpEF) found that, although spironolactone initiation increased following the TOPCAT trial, there was no corresponding rise in hyperkalemia-related hospitalizations [56]

Blood 118(21):1113, 2011

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