Clinical research shows both can help people lose weight, but bioavailability and dosing schedules differ significantly between them
Biomedicines, 9(10), 1300.
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More specifically, an in vivo study, based on chronic 40-day peripheral administration of lixisenatide to high-fat fed mice with established obesity, insulin resistance and impaired cognition, found that lixisenatide significantly upregulated expression of the neurotrophic tyrosine kinase receptor type 2 ( NTRK2 ) gene and of the mammalian target of rapamycin ( mTOR ) gene in the hippocampus, which are involved in regulating synaptic plasticity [100]
Translation will depend on whether these outputs can be operationalised within decision-support systems that integrate seamlessly into practice, and whether prospective trials demonstrate improved patient-relevant outcomes under biomarker-guided care [291, 483]
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