As per one study, IL-37 suppresses TNF- [163], whereas, the other study shows a positive correlation between IL-37 and TNF- levels [164]
Although beneficial under normal circumstances, the drug efflux attributes of P-gp can be the leading cause for diminishing, if not nullifying, the efficacy of anti-cancer agents against cancer cells [11, 13, 28, 32, 34]
The Notch, Hedgehog, and PI3K/AKT/mTOR pathways combine to sustain the core features of CSCs: a slow-cycling or quiescent state that evades traditional chemotherapies, enhanced DNA repair pathways that mitigate genotoxic stresses, and a tendency to give rise to differentiated progeny that form the bulk of a tumor
This difference is explained further in the comparison of IV therapy vs oral supplements
Oral glutathione increases tissue glutathione in vivo
PLoS One 7 , e29763 (2012)