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Although it is rare, death in adults resulting from gastrointestinal complications has occurred in the past

Combined with a GLP-1 medication, the electrolyte losses can be substantial

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While direct head-to-head trials have not been conducted, cross-trial comparisons provide useful context

3,5 In early T2DM managed with lifestyle alone, orforglipron lowered glycated hemoglobin A1c (HbA1c) by -1.24 to -1.48 percentage points over 40 weeks as compared to -0.41 with placebo, with no severe hypoglycemia reported and weight reduction ranging from 4.5% to 7.6%, 3 which led to mean HbA1c levels of 6.5-6.7%