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NNMT inhibition by 5-Amino-1MQ preserves the cellular nicotinamide pool important for NAD+ biosynthesis and conserves the methyl-donor pool by reducing SAM consumption

In addition, the committee recommends the identification of biomarkers specifically related to proposed mechanisms of action for individual nutritional interventions

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Dihexa doesn't need to remain in circulation to drive neuroplasticity because it initiates structural changes in hippocampal neurons that continue long after the peptide clears from plasma

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10.3390/ijms20071680 98 LeeT