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Moreover, it has recently been reported that metformin inhibits the apical sodium-dependent bile acid transporter and thus may increase the concentration of bile acids in the intestine [12], which could stimulate GLP-1 secretion from L cells via the G-protein-coupled receptor TGR5 [13]

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Its part of a class of drugs called GLP-1 receptor agonists (glucagon-like peptide-1), which mimic a hormone in your body that helps regulate blood sugar, insulin levels, and appetite

Ross Wollen Author Ross Wollen joined Everyday Health in 2021 and now works as a senior editor, often focusing on diabetes, obesity, heart health, and metabolic health

The three arms of the mechanism each contribute a distinct effect: GLP-1 receptor agonism drives central appetite suppression and slowed gastric emptying