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Foundational NNMT Discoveries The foundational research establishing NNMT as a metabolic regulator and potential therapeutic target came from studies by Daniel Kraus and colleagues published in Nature in 2014, which demonstrated that NNMT expression is dramatically upregulated in adipose tissue of obese humans and diet-induced obese mice, and that genetic knockdown of NNMT in mice protected against diet-induced obesity and improved metabolic parameters

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To further investigate whether HA-Ssu72 expression could reduce GSK3 phosphorylation in Ssu72-deficient eWAT, immunoblotting analysis was performed

Its effectiveness depends on treating the underlying cause, so that long-term relief may require additional medical treatment

About 40% of participants lost 25% or more

Metabolic drugs expanded beyond weight and glucose