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Reducing rapid acting meal time insulin by 30-50% is recommended during the initial dose titration period (427)

Gastroparesis diagnosis typically requires medical professionals to conduct gastric emptying studies, confirming delayed stomach emptying while excluding mechanical obstruction possibilities

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Randomized trials show a low absolute incidence, but post-market surveillance suggests the real-world risk may be higher in vulnerable populations

Our findings provide a new mechanistic insight into the resistance of IGF-1R inhibition in which MEK1/2 activation stimulates the survival signal (Fig