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When it was discovered that very high doses of B12 were required for older adults to minimize their MMA levels, we raised our recommendations for older adults

Animal data indicates rapid clearance typical of unmodified small peptides, generally minutes to low hours in plasma

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There are many possible causes of B12 deficiency eg diet, PA, Coeliac disease, H Pylori infection, Crohns disease, internal parasites such as fish tapeworm, exposure to nitrous oxide plus others

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