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Using these resources, researchers recently produced the first stable edited lines of grain amaranth by targeting the betalain pathway, generating non-pigmented mutants (Priyadarsini et al., 2025

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For example, the efficacy of several small molecular targets has been well demonstrated in animal models, such as mGluR5 inhibitors, OT, Memantine, and mTOR inhibitors, but is still unsatisfactory in clinical trials

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Additionally, NKX2-2, a recognized embryonic stem cell transcription factor, was demonstrated to transcriptionally activate KIAA1429 and other m6A RNA methylation writers, hence amplifying oncogenic signaling

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