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Every four weeks, the dose is gradually escalated (to 0.5 mg, 1.0 mg, 1.7 mg, and finally the maintenance dose of 2.4 mg per week) until the patient reaches their target clinical maintenance level

GLP-1 receptors also exist in the chemoreceptor trigger zone, a brain region responsible for nausea signals

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These situations require professional evaluation to determine whether technique adjustment, dose modification, or a delivery method change is appropriate