Harrison IF, Smith AD, Dexter DT (2018) Pathological histone acetylation in Parkinsons disease: Neuroprotection and inhibition of microglial activation through SIRT 2 inhibition
Even though hydroquinone is the workhorse, there are novel products that may soon replace hydroquinone
6,30 Pregnancy: All DPP-4 inhibitors are considered Pregnancy Category B because safety in humans has not been proven in adequate and well-controlled studies
Disruptions in mitochondrial function lead to increased oxidative stress, cellular damage, and eventual neurodegeneration (Anderson et al., 2023)
This differs from GLP-1 medications, where appetite suppression reverses within days of stopping
The next, phase 1b clinical trial in adults with T2DM compared once weekly retatrutide (0.5, 1.5, 3, 3 mg starting dose increased to 6, 3 mg starting dose increased to 12 mg) versus placebo versus dulaglutide 1.5 mg over 12 weeks [63]