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Cerebral pharmacokinetics and microdialysis To confirm that a peptide actually reaches its cerebral target, microdialysis remains the reference tool: Principle : insertion of a semi-permeable membrane probe in a target region (hippocampus, frontal cortex)

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A375 cells were cultured until 3050% confluence, then treated with a complete growth medium containing 0.1 M doxorubicin (Sigma D1515)