Loose skin is not a side effect of Wegovy itself
For the broader class, STEP studied semaglutide for weight management (NEJM 2021)
This outcome is thought to be an effect of all medications that increase GLP-1, because of both an increase in SDF-1-alpha and capillary density due to increased hypoxia-inducible factor 1-alpha and vascular endothelial growth factor
Why Genetic Testing Helps Optimize Your Semaglutide Dose The PlexusDx Precision Peptide Genetic Test analyzes GLP1R (rs6923761), FTO (rs9939609), and MC4R (rs17782313) variants that relate to GLP-1 and related signaling pathways
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Dysregulation of copper ions can disturb lipid metabolism, resulting in oxidative stress, mitochondrial damage and endothelial cell dysfunction (14), and induce atherosclerosis and other cardiovascular diseases such as arrhythmia and cardiomyopathy (15)
