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Protein aggregation-driven UPS impairment in sporadic NDDs In addition to genetic mutations, UPS dysfunction is also a defining feature of sporadic NDDs, where aggregation-prone proteins directly impair proteasomal function

Head Neck 37:727734 Mimura J, Inose-Maruyama A, Taniuchi S, Kosaka K, Yoshida H, Yamazaki H, Kasai S, Harada N, Kaufman RJ, Oyadomari S, Itoh K (2019) Concomitant Nrf2- and ATF4-activation by carnosic acid cooperatively induces expression of cytoprotective genes

Acetylcysteine may be introduced directly into a particular segment of the bronchopulmonary tree by inserting (under local anesthesia and direct vision) a small plastic catheter into the trachea

To administer an SC injection, a 25 to 30 gauge, 3/8 in

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