Note: This data comes from clinical trials
Important Caveats: This observation is anecdotal, not registry-derived It is not a substitute for controlled epidemiology It provides real-world context consistent with MTC rarity and absence of compelling causal signals in highest-quality human evidence Clinical Significance: In a practice seeing more thyroid cancer than anywhere globally, we are not observing an MTC wave in GLP-1 users
It binds with high affinity to hepatocyte growth factor (HGF) and interacts with its receptor, c-Met
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Davies MJ, Aroda VR, Collins BS, Gabbay RA, Green J, Maruthur NM, Rosas SE, Del Prato S, Mathieu C, Mingrone G, Rossing P, Tankova T, Tsapas A, Buse JB