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The authors argued that the lack of therapeutic efficacy could be due to systemic distribution or distribution outside the joint after intra-articular injection

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Instead, the pinealon peptide is a much smaller molecule than semorelin, and its size suggests that it may be able to travel through the bloodstream and cross into brain tissue, reaching neurons directly to target cellular and neurological pathways

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At 1,400mg, Fireball delivers LCLT at a meaningful single-serving dose the research on LCLT's performance effects operates in the 1-3g range, and 1,400mg as a standalone contribution is positioned in the lower-to-mid range of the effective research window.

Int J Mol Sci 9:24472473