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355,356 The BBB not only allows highly selective permeability of substances entering and exiting through specialized structures (seal off adjacent BECs) but also dynamically regulates cerebral blood flow through the process of neurovascular coupling, maintaining homeostasis and neuronal function in the CNS

These claims often involve extensive review of medical records, autopsy findings, hospitalization history, prescription records, and expert medical opinions regarding causation

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Moreover, recent studies have demonstrated that IL-1 treatment could promote ferroptosis and decrease the level of GPX4 protein in chondrocytes [22, 112]

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