Perceived energy and wellbeing Some users report feeling more energy or better tolerance to exercise
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However, because semaglutide changes how the body processes food and delays how quickly the stomach empties, it raises questions about whether it might interfere with the absorption of other medications, such as birth control pills

Seek medical advice if fatigue: Persists beyond several months without improvement, despite adequate nutrition and hydration Worsens progressively or becomes debilitating, significantly impairing daily activities or work capacity Is accompanied by severe or persistent gastrointestinal symptoms (intractable nausea, vomiting, diarrhoea, abdominal pain) Occurs alongside signs of dehydration (dark urine, dizziness, reduced urine output, dry mouth) Is associated with symptoms of hypoglycaemia (tremor, sweating, confusion, palpitations), particularly in patients taking concurrent insulin or sulphonylureas Urgent medical attention is required if patients experience: Severe abdominal pain , especially if radiating to the back, which may indicate pancreatitisa rare but serious adverse effect of GLP-1 medications
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235 Additionally, the oxidation of guanosine to 8-oxo-2-deoxyguanosine (8-oxodG) at CpG sites directly interferes with methylation