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The results mirror a previous observation from our group, that hypothalamic Gipr KO appeared to sensitize DIO mice to weight loss induced by a long-acting GLP-1R agonista finding that had not been the focus of that study and remained unexplained at the time but has since also been observed in global GIPR-KO mice 7,11

Amplification was performed in duplicate with the ABI 7300 system (Applied Biosystems) with the following profile: 50 for 2 min, 95 for 10 min, and 40 cycles of 95 for 15 s, and 60 for 1 min

Key takeaway: Alzheimers may not be inevitable. APP responds to hormones, inflammation, and nutritionmeaning lifestyle is one of the most powerful tools we have to protect the brain

Diabetes 60, 14141423

Benefits: Well-absorbed when taken orally

Month 9: Kim enjoyed more weight loss milestones and embraced appetite control with Nooms GLP-1 support