Taking a medication roughly 12 times a year could materially increase adherence rates
Mulvihill EE, Varin EM, Gladanac B et al (2017) Cellular sites and mechanisms linking reduction of dipeptidyl peptidase-4 activity to control of incretin hormone action and glucose homeostasis
The guidelines warn, however, that GLP-1 receptor agonist therapy is not indicated for all patients and should be used with caution in patients with a history of significant gastrointestinal disease, such as a diagnosis of gastroparesis, due to a possible exacerbation of the condition with incretin mimetic therapy
If you fall into this category, semaglutide is a game-changer
Dow, J., Simkhovich, B
Notably, several microbial features observed in non-responders overlap with taxa previously associated with greater T2D severity and pro-inflammatory metabolic states (70, 134)