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562 pyridostigmine, an acetylcholinesterase inhibitor that augments sympathetic ganglion transmission to increase vascular resistance during standing without significantly affecting supine blood pressure
That is, the amount of drug required to induce efficacy is 6,000 and 30,000 times greater in bioavailable aqueous concentration of the drugs compared to their nanomolar efficacy
A.OlsonA
This is consistent with microgravity-induced overproduction of ROS, leading to oxidative stress and DNA damage, which compromise endothelial cell function and cause the vascular pathologies observed in astronauts 5
J.UtleyR
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