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The active GST complex catalyzes the -SH residue on glutathione to perform a nucleophilic attack on electrophilic carbon, sulfur, or nitrogen atoms of the xenobiotic substrate

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Retatrutide is in Phase 3 clinical trials through Eli Lilly, and cagrilintide is in Phase 3 trials through Novo Nordisk (both as monotherapy and as part of CagriSema)

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