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Notably, mutating the nuclear localization signal (NLS: 640PKLKRQ646) of CUL5 (e.g., K642G/K644G mutations) significantly diminishes its nuclear translocation, impairing its ability to suppress cell proliferation (9)

About one in seven adults who have ever used GLP-1 medications say they are no longer using these drugs because of the cost (14%), similar to the share who report no longer taking the medications because of side effects (13%)