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Our findings suggest that NHPN-1010 plays a therapeutic role in NIT by promoting cochlear synaptogenesis and normalizing central auditory signaling

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Naloxone as a neutral antagonist, do not have risk for overdose [90] .In non-dependent opioids patients, naloxone has a high tolerability profile as opioid withdrawal is the most frequently reported adverse effect with symptoms of nausea, irritability, vomiting, and anxiety [91]