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Peripheral neuropathy, subacute combined degeneration of the spinal cord, or cognitive impairment indicate more advanced deficiency and generally require intensive treatment over extended periods

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Adjustments follow data such as dose changes, switching peptides, adding supportive therapies like anti-inflammatories, or pausing treatment if adverse events occur

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Another issue of concern that must be comprehensively explored in future trials is the association between tesofensine and increased frequency of agitation and mood changes

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