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164 In addition, hyperglycemia and other metabolic disorders such as dyslipidemia, inflammatory factors, excess IAPP and alterations in the gut microbiota, combine to contribute to IR and/or cell dysfunction through the common pathways of inflammation, ERS and oxidative stress (Fig

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Immediately after cessation of semaglutide treatment, food intake significantly increased to levels above those observed in vehicle-treated mice ( Figure 2A-B )