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Then, PLGA-nanoparticles active targeting by both overexpression of Epidermal Growth Factor Receptor (EGFR) and transferrin-conjugated (TfR) enhanced cellular uptake of TMZ alone and in combination with Bortezomib (BTZ) (43, 72)

However, patients rarely may develop severe non-IgE-mediated immune drug reactions (e.g., Steven Johnson Syndrome, acute interstitial nephritis)

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& Landas, S

A separate study published in the International Journal of Pharmaceutics found over 7-fold greater oral bioavailability in rat models for the arginate form compared to acetate