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Discussion Recent publications of positive CV outcome trials with SGLT2i (empagliflozin and canagliflozin) and GLP1 RA (liraglutide and semaglutide) and the positive effects of treatment with these drugs utilizing the pathophysiological defects of T2D have caused a paradigm shift in the way the disease is treated [1,2,3,4]

It also slows gastric emptying, leading to a decrease in food intake, which assists in body weight reduction

The reality is that foundational therapies, while essential, sometimes cannot fully address the deep-seated mechanisms driving the autoimmune process

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Non-hormonal options including copper IUDs, barrier methods (condoms, diaphragms), and behavioral methods (fertility awareness) work independently of medication interactions and can be used safely alongside semaglutide without concern

Hu et al., 2025