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Synthesis and secretion of GLP-1 The regulation of GLP-1 synthesis is one mechanism by which the GLP-1 and GLP-1r system can be customized

- Pipeline shift: Pharma companies are moving away from traditional therapies and investing more into multi-agonist therapies such as GLP-1/ glucagon, GLP-1/Gastrin to achieve high efficacy with minimum toxicity

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Nature 412 , 549553 (2001)