Sustained inflammatory insults induce cumulative DNA damage and epigenetic reprogramming, fostering malignant transformation through two synergistic mechanisms: (1) persistent immune cell activation (neutrophils, macrophages, lymphocytes) and (2) tumor co-option of inflammatory mediators (IL-6, TNF-, COX-2) as metastatic accelerants
Because angiogenesis is a defining hallmark of tumor growth and metastatic progression, any therapeutic agent that enhances neovascularization could, in theory, facilitate tumor expansion and promote metastatic dissemination
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After four weeks, your healthcare provider will increase the tirzepatide dosing for weight loss in units to 5 mg weekly and continue gradual escalation every four weeks until reaching your optimal maintenance dose