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Tirzepatide is a novel dual agonist that targets both the GLP-1 receptor and the glucose-dependent insulinotropic polypeptide (GIP) receptor (13, 14)

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Patients should undergo TSH and free thyroid hormone testing every 68 weeks during the first months of semaglutide therapy, then every 3 months as treatment stabilizes, to detect any shifts requiring antithyroid or replacement hormone adjustment

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