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Several factors may hinder the absorption of natural food folate, e.g., partial release from the food matrix (incomplete liberation from cellular structures), destruction within the gastrointestinal tract, and incomplete hydrolysis of polyglutamates to monoglutamates (possibly mediated by partial inhibition of deconjugation enzymes by other dietary constituents such as organic acids)

You may qualify if: Your BMI is greater than 27 , with or without weight-related medical conditions

Typical schedule is weekly for the first month, then every 24 weeks based on how you respond and your B12 levels

The dose escalation protocol exists specifically to minimize these effects

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This dose-independent pricing model eliminates the financial burden that typically discourages patients from achieving optimal therapeutic dosing