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It references a HOMA-IR above 2.5 as a marker of that insulin-resistant group

By decreasing glucagon release, these agonists support the body in maintaining more consistent blood sugar levels, which not only aids in weight loss but also provides overall metabolic benefits

Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for two primary indications: type 2 diabetes mellitus (marketed as Mounjaro) and chronic weight management (marketed as Zepbound)

Psychiatry 134 , 382389 (1979)

Both studies used the ingredient at 0.1% which also matches how much it usually shows up in products (at fractions of a percent)

Both are FDA-approved for adults with a body mass index of 30 or higher, or 27 or higher with at least one weight-related condition such as high blood pressure or high cholesterol