Dose-response effects on HbA(1c) and bodyweight reduction of survodutide, a dual glucagon/GLP-1 receptor agonist, compared with placebo and open-label semaglutide in people with type 2 diabetes: a randomised clinical trial
ML226 sometimes appeared to increase total OGDH-E2 levels
doi: 10.1093/humrep/dex044 8 WaltersKABertoldoMJHandelsmanDJ

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Modulation of glycolytic enzymes Modulation of the expression of specific metabolic genes and the activity of glycolytic enzymes, such as lactate dehydrogenase (LDH), can significantly inhibit T cell exhaustion and enhance the antitumor effect of CD8 + T cells
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