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Furthermore, a significant number of these patients (between 20 to 40 percent) may become tolerant to this procedure, causing it to become less effective over time

Leite S, Oliveira-Pinto J, Tavares-Silva M, Abdellatif M, Fontoura D, Falco-Pires I, et al

Similarly, ferroptosis-mediated cell death that results in the release of 8-hydroxylamine (8-OHG) activates the STING1-dependent inflammatory pathway in surrounding macrophages and promotes M2 polarization [115]

20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO SECTION 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of February, 2026 Commission File Number: 001-36815 Ascendis Pharma A/S (Exact Name of Registrant as Specified in Its Charter) Tuborg Boulevard 12 DK-2900 Hellerup Denmark (Address of principal executive offices) Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F