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Are we somehow nutritionally depleting the women anticipating pregnancy

Si, C., Cao, Y

Enter GLP-1 agonists (you may have heard of them as weight-loss injections)

Neurogenesis, synaptic plasticity, and metabolic support GLP-1R stimulation promotes hippocampal neurogenesis and enhances synaptic plasticity, partly through brain-derived neurotrophic factor and modulation of glutamatergic signalling

According to US obesity treatment guidelines, continuation of therapy should be reassessed if a patient has not lost at least 5% of baseline weight after approximately 3 months on the maintenance dose