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In biological systems, ascorbic acid can be found only at low pH, but in solutions above pH 5 it is predominantly found in the ionized form, ascorbate

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Some, however, including certain birds, guinea pigs, bats, primates, and humans, lack the necessary biosynthetic apparatus and must acquire vitamin C through external sources, i.e., diet

30 Notably, there were no significant differences in DPP4 expression on the membrane of circulating monocytes and lymphocytes between healthy controls and patients with pre-clinical RA

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