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This suggests the medication's appetite-suppressing effects matter more than dietary perfection for achieving measurable results

The GIP receptor component works alongside GLP-1 to amplify the insulin response, and the glucagon receptor component, which is absent in semaglutide and tirzepatide, signals the body to burn stored fat rather than conserve it

Rodriguez et al., 2025), with those without T2DM exhibiting even higher rates of discontinuation than those with T2DM (Rodriguez et al., 2025)

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