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In addition, DHA induced ferroptosis as an antitumor agent in primary liver cancer (PLC) by activating the anti-survival unfolded protein response (UPR) and upregulating Chac GSH specific -glutamylcyclo-transferase 1 (CHAC1) expression, which was significantly attenuated by Fer-1 and DFO application after iron loading (95)

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Treatment duration and review should follow NICE guidance for Wegovy (TA875), which specifies a maximum treatment duration of 2 years and continuation only if at least 5% weight loss is achieved at 6 months