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147 These investigators also measured bladder nitric oxide as a putative marker for treatment effects

Although symptomatic therapies like Levodopa and Deep Brain Stimulation (DBS) offer short-term relief, they fail to alter disease progression or address the wide array of nonmotor symptoms and comorbidities

2.14.1 Therapeutic investigations Several groundbreaking investigations have revealed the neuroprotective effects of natural compounds using Kunming mice

When the calcium binds to a protein called synaptotagmin, on the vesicles' surfaces, synaptotagmin teams up with other proteins to tug some of the vesicles, winch-style, closer and closer to the neuron's surface membrane until their enclosing membranes fuse with it, spilling the vesicles' contents into the surrounding environment

Aging Cell 19 (11), e13261