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Tricyclic antidepressants (TCAs) Amitriptyline and nortriptyline: Effective in managing PDPN by inhibiting monoamine reuptake and blocking sodium channels

Landmark 2017 Cell paper One of the foundational studies (by Baar et al.) was titled Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. This work demonstrated: In mice that were aged or given chemotherapy (accelerated ageing), treatment with FOXO4-DRI improved physical performance, fur quality, and renal function

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HUBERMAN: Involves a lot of turnover of cells because as you know if you cut your skin, at some point it will heal up

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